Containment Barrier Isolator

Esco Containment Barrier Isolator (CBI) facilitates the isolation of a product or process while providing the required conditions for a sterile/aseptic environment. It is configured to operate at positive or negative pressure. This equipment provides a comprehensive range of personnel and product protection in addition to protection for the surrounding work areas and the environment.

CBI’s design has complete compliance to PIC/s and EU cGMP standards with its 19 mm radius coved internal corners in a single piece chamber (no perforations or grilles for contaminants to be trapped on all 4 corners). Its Rear Return Filter ensures that ducts are not contaminated. The system comes in either recirculatory or single pass airflow.


  • Pharmacy Compounding (Chemotherapy/TPN)
  • As a Class III Cabinet for Biosafety Levels (BSL) 3 and 4
  • Small Batch Sterility Testing
  • Small-scale Potent Material Handling
  • Cell Processing
  • Aseptic Processing
  • Research and Development
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Product Description


  • Controls exposure/cross-contamination risk to hazardous/aseptic materials for a wide variety of equipment and processes
  • Controls false-positive risk for sterility testing
  • Provides Operator Exposure Levels (OEL’s) ≤1.0 μg/m3 during controlled operations
  • Levels of ≤0.1 μg/m3 can be achieved via closed-transfer processes or based on client SOPs
  • Enhances cGMP practices
  • Quiet, energy-efficient ECM fans auto adjust to compensate for filter blockage
  • Standard dimensions available are easily customized to suit process requirements
  • Safe glove change and low contamination filter change
  • FDA-approved static seals
  • Class 2 containment enclosure on manual pressure leak test and Class 3 containment enclosure on automated pressure test as per ISO 10648-2
  • System comes with a Semi-automated or Automated Pressure Hold Testing
  • Pass Chamber comes in 2 sizes:
    • Small, non-gloved
    • Large, non-gloved/gloved

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